基于羧基化多壁碳纳米管的双苯基吡唑修饰及合成产物的细胞毒性研究

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1. Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran;

2.
Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon| Iran

Functionalization of carboxylated multi-wall carbon nanotubes with 3,5-diphenyl pyrazole and an investigation of their toxicity

1. Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran;

2.
Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon| Iran

摘要: 采用化学修饰方法，在羧基化多壁碳纳米管的基础上，合成制备了酮化和吡唑化多壁碳纳米管材料。通过红外光谱、拉曼光谱、扫描电镜、元素分析、热失重分析对产物进行了理化性质表征，并在人脐带血衍生的非限制性体干细胞（USSC）上研究了该产物的细胞毒性。结果显示，酮化多壁碳纳米管的细胞毒性低于吡唑化多壁碳纳米管。
- 碳纳米管 /
- 吡唑 /
- 功能化 /
- 毒性 /
- 热重
Abstract: Carboxylated multi-wall carbon nanotubes (MWCNT-COOH) were first modified by 1,3-diphenylpropane-1,3-dione to form a MWCNT-ketone and then by hydrazine to produce MWCNT-pyrazole. All modified samples were characterized by FT-IR, Raman spectroscopy, SEM, elemental analysis, TGA, DTG. Their interactions with living cells were investigated. The toxicity of the samples was evaluated with unrestricted somatic stem cells and viable cell numbers were measured by reduction of living cells with 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. Results indicated that there is one diketone group in MWCNT-ketone and one 3,5-diphenyl pyrazole group in MWCNT-pyrazole per 28 and 72 carbon atoms of MWCNTs, respectively. MWCNT-ketone had the lowest toxicity in all samples investigated.
- Carbon nanotube /
- Pyrazole /
- Functionalization /
- Toxicity /
- TGA