硝苯地平在球状活性炭中的吸附及缓释行为

吕春祥; 凌立成; 袁淑霞; 梁栋; 李永红

硝苯地平在球状活性炭中的吸附及缓释行为

中国科学院炭材料重点实验室中国科学院山西煤炭化学研究所,山西太原 030001;2.中国科学院研究生院,北京 100039;3.华东理工大学化工学院,上海 200237

详细信息

通讯作者:
吕春祥

中图分类号: TQ 424.1
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出版历程
- 收稿日期: 2007-01-02
- 录用日期: 2007-03-20
- 修回日期: 2007-02-15
- 刊出日期: 2007-03-20

硝苯地平在球状活性炭中的吸附及缓释行为

Key Laboratory of Carbon Materials,Institute of Coal Chemistry,Chinese Academy of Sciences,Taiyuan 030001,China; 2.Graduate School of the Chinese Academy of Sciences,Beijing 100039,China; 3.College of Chemical Engineering, East China University of Science and Technology,Shanghai 200237,China

More Information

Corresponding author: LU Chun-xiang

摘要

摘要: 采用球状活性炭作为硝苯地平药物载体，借助N2吸附仪表征了球状活性炭的比表面积和孔结构，利用SEM表征了球状活性炭的表面形貌，通过考察球状活性炭比表面积、孔隙结构与吸附性能和体外释放性能的关系，研究了球状活性炭对硝苯地平的吸附及缓释行为。结果表明：比表面积大、孔隙结构发达、孔径分布集中在2nm~5nm之间的中孔型活性炭，对硝苯地平的吸附能力较强，吸附量可达19.5mg/g；所制缓释微丸缓释效果良好，在接近人体胃液介质中累计释放率达到19.2％；球状活性炭对硝苯地平的释放动力学符合Higuchi模型，药物基本以恒定速率主动释放。
- 球状活性炭,缓释,硝苯地平
Abstract: Adsorption of nifedipine by spherical activated carbons (SACs) and their invitro release behavior were investigated. The pore structure, specific surface area and surface morphologies of the SACs were tested by N2 adsorption and SEM. The relationship between pore structure, specific surface area and adsorption/in-vitro release behavior was discussed. Results indicated that SACs with a high specific surface area and abundant mesopores ranging between 2nm and 5nm exhibited excellent adsorption and in-vitro release of nifedipine. The maximum adsorption capacity was 19.5mg/g, and the total release rate can reach 19.20%. The release dynamics of SACs containing nifedipine are in accordance with the Higuchi model, which shows that the release speed is a constant.
- Spherical activated carbons,In-vitro release,Nifedipine