功能化洋葱状富勒烯在裸鼠体内的流动

基金项目: 国家自然科学基金(50772069)和教育部资助项目（NECT-08-0888，209018）.

Fluidity of onion-like fullerenes in mice aftera functionalization modification

1.
College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China|
2.
Medical College, Zhejiang Ocean University, Zhoushan 316004, China

Funds: Natural Science Foundation of China (50772069) and Science Foundation of Ministry of Education of China (NECT-08-0888，209018).

摘要: 采用L-半胱氨酸盐酸盐，通过化合接枝法对洋葱状富勒烯进行功能化，合成水溶性L半胱氨酸富勒烯衍生物。利用扫描电子显微镜（SEM）、X射线衍射（XRD）、红外光谱（IR）、热重分析（TGA）及X射线能谱分析（XPS）对所制样品进行表征。结果表明：L-半胱氨酸富勒烯衍生物表面具有-OH、-NH₃等亲水性基团，水溶性良好。裸鼠实验表明，合成的L-半胱氨酸富勒烯衍生物在生物体组织细胞中具有很好的分布，可以顺利溶入生物体体液并具备良好的流动性。
- L-半胱氨酸富勒烯衍生物 /
- 水溶性 /
- 功能化 /
- 流动性
Abstract: Water-soluble onion-like fullerene (OLF) derivatives were prepared by chemical bonding of L-cysteine, an important amino acid in organisms, to OLFs. The L-cysteine OLFs were characterized by SEM, XRD, IR, TGA and XPS. Results showed that hydrophilic groups added to the surface of OLFs such as -OH and -NH₃ made L-cysteine OLFs good water-soluble derivatives. Experiments in mice demonstrated that the water-soluble fullerene derivatives were well distributed in the histolytic organism because of their excellent solubility and fluidity in humoral liquid.
- L-cysteine onion-like fullerenes(OLFs) /
- Solubility /
- Functional modification /
- Fluidity