镧修饰羧基化氧石墨烯的抑菌性能

王晓丹1; 2; 周宁琳1; 2; 3; 汪炜燕1; 2; 汤毅达1; 2; 章　峻1; 2; 3; 沈　健1; 2; 3

镧修饰羧基化氧石墨烯的抑菌性能

南京师范大学江苏省生物医药功能材料工程研究中心|江苏南京 210097;
南京师范大学江苏省生物功能材料重点实验室|江苏南京 210097;

基金项目: 江苏省自然科学基金(BK2009408)，国家自然科学基金(20874047),江苏高校优势学科建设工程资助项目（PAPD），江苏省产学研前瞻性联合研究项目（BY2011109）

详细信息

作者简介:
王晓丹（1985-）|女|辽宁辽阳人|硕士生|主要从事生物功能材料的学习与研究. E-mail: wxd 851127@yahoo.cn

王晓丹（1985-）|女|辽宁辽阳人|硕士生|主要从事生物功能材料的学习与研究. E-mail: wxd 851127@yahoo.cn

王晓丹（1985-）|女|辽宁辽阳人|硕士生|主要从事生物功能材料的学习与研究. E-mail: wxd 851127@yahoo.cn

王晓丹（1985-）|女|辽宁辽阳人|硕士生|主要从事生物功能材料的学习与研究. E-mail: wxd 851127@yahoo.cn

王晓丹（1985-）|女|辽宁辽阳人|硕士生|主要从事生物功能材料的学习与研究. E-mail: wxd 851127@yahoo.cn

王晓丹（1985-）|女|辽宁辽阳人|硕士生|主要从事生物功能材料的学习与研究. E-mail: wxd 851127@yahoo.cn

中图分类号: 　O 61　TB 333
计量
- 文章访问数: 1878
- HTML全文浏览量: 138
- PDF下载量: 1254
- 被引次数: 0
出版历程
- 收稿日期: 2012-08-25
- 录用日期: 2012-10-31
- 修回日期: 2012-10-02
- 刊出日期: 2012-10-20

The antimicrobial properties of carboxylated graphene oxide decorated with La particles

Nanjing Normal University, Jangsu Engineering Research Center for Biomedical Functional Materials| Nanjing 210097, China|
Nanjing Normal University, Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Environmental Science, Nanjing 210097| China |

Funds: The project was supported by the National Natural Science Foundation of China (20874047), Natural Science Foundation of Jiangsu Province(20874047) , Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD) and Base of production, education & research of prospective joint research project of Jiangsu Province (BY2011109).

More Information

Author Bio:
WANG Xiao-dan (1985-), female, Master of Science (MS) in reading, engaged in the study of nanotechnology and biomedical function materials. E-mail: wxd851127@yahoo.cn

WANG Xiao-dan (1985-), female, Master of Science (MS) in reading, engaged in the study of nanotechnology and biomedical function materials. E-mail: wxd851127@yahoo.cn

WANG Xiao-dan (1985-), female, Master of Science (MS) in reading, engaged in the study of nanotechnology and biomedical function materials. E-mail: wxd851127@yahoo.cn

WANG Xiao-dan (1985-), female, Master of Science (MS) in reading, engaged in the study of nanotechnology and biomedical function materials. E-mail: wxd851127@yahoo.cn

WANG Xiao-dan (1985-), female, Master of Science (MS) in reading, engaged in the study of nanotechnology and biomedical function materials. E-mail: wxd851127@yahoo.cn

WANG Xiao-dan (1985-), female, Master of Science (MS) in reading, engaged in the study of nanotechnology and biomedical function materials. E-mail: wxd851127@yahoo.cn

摘要

摘要: 在氧化石墨烯（GO）的研究和应用中, 为充分发挥其优良性质,必须对其进行功能化。笔者将稀土La3+离子接枝到羧基化的GO（GO-COOH）片层上, 制备了一种功能化的镧修饰羧基化氧石墨烯（La/GO-COOH）。利用红外光谱、热重分析和透射电镜等手段对合成的La/GO-COOH进行了表征, 结果表明，La3+已通过化学和物理作用吸附在GO片层上。通过细菌生长动力学实验评价了La/GO-COOH的抑菌性能, 结果表明，La/GO-COOH对大肠杆菌有很好的抑菌效果, 当浓度为0.5mg/mL, 抑菌率达96.40%；对金黄色葡萄球菌和铜绿假单胞菌也均有抑菌效果，因此La/GO-COOH是具有抑菌性能的新型GO负载物；与未剥离的镧修饰氧化石墨（La/GTO）相比,由于剥离的GO片层的比表面积大，其吸附La3+离子的量高于氧化石墨（GTO）, 故La/GO-COOH复合物的抑菌性远优于La/GTO。
- 氧化石墨烯 /
- 氧化石墨 /
- 三氯化镧 /
- 细菌生长动力学
Abstract: Graphene oxide (GO) was functionalized by acetyl chloride to form carboxylated graphene oxide (GO-COOH). GO-COOH decorated with La particles with diameters between 0.2 and 1 μm was prepared by the sonication of a LaCl3 aqueous solution with GO-COOH. The La-decorated GO-COOH was characterized by FT-IR, TGA and TEM, and its antibacterial properties were characterized by bacteria growth kinetics. Results showed that the La3+ ions were coordinated on edges and corrugated parts of the GO-COOH by physical and chemical bonding. The La-decorated GO-COOH had a good inhibitory efficiency of 96.4% on the E.coli when its concentration was 0.5 mg/mL. It also had inhibitory effects on S.aureus and the P.Aeruginosa. The better antibacterial effect of the La-decorated GO-COOH than the corresponding La-decorated GTO was ascribed to the higher amount of La particles incorporated on the GO-COOH.
- Graphene oxide /
- Graphite oxide /
- Lanthanum trichloride /
- Kinetics of bacterial growth