荧光碳点的制备及其肿瘤诊断和治疗中的应用研究进展

吕春祥; 李利平

荧光碳点的制备及其肿瘤诊断和治疗中的应用研究进展

吕春祥^1,2,,
李利平^1,3,4

1.
中国科学院山西煤炭化学研究所, 中国科学院炭材料重点实验室, 山西太原 030001;
2.
碳纤维制备技术国家工程实验室, 山西太原 030001;
3.
中国科学院大学, 北京 100049;
4.
山西医科大学, 山西太原 030001

详细信息

通讯作者:
吕春祥,研究员.E-mail:lucx@sxicc.ac.cn

中图分类号: TQ127.1⁺1
计量
- 文章访问数: 425
- HTML全文浏览量: 117
- PDF下载量: 761
- 被引次数: 0
出版历程
- 收稿日期: 2017-10-10
- 录用日期: 2018-02-11
- 修回日期: 2018-01-22
- 刊出日期: 2018-02-28

Progress in research on the preparation of carbon dots and their use in tumor theranostics

LU Chun-xiang^{1,2
,},
LI li-ping^1,3,4

1.
Key Laboratory of Carbon Materials, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, China;
2.
National Engineering Laboratory for Carbon Fiber Technology, Taiyuan 030001, China;
3.
University of Chinese Academy of Sciences, Beijing 100049, China;
4.
Shanxi Medical University, Taiyuan 030001, China

摘要

摘要: 碳点是一种新型的碳基荧光纳米材料，因具有优异的荧光性能、低毒性、良好的水溶性及表面易修饰等优点，在生物医学领域有很好的应用潜力。本文重点从工艺的角度对碳点的制备进行阐述，介绍红光和近红外荧光碳点的研究进展，及碳点在诊断和治疗肿瘤方面的应用研究，探讨目前碳点发展的限制因素及未来的发展趋势。
- 碳点 /
- 制备 /
- 红光 /
- 诊断和治疗
Abstract: Carbon dots (CDs), as a novel class of carbon-based nanomaterials, have attracted tremendous attention in biomedicine owing to their excellent optical properties, low toxicity, good water solubility and easy surface modification. In this review, we introduce various methods for their synthesis based on technology and recent research progress on red-emission and near-infrared emission CDs, and address the use of CDs in the diagnosis and therapy treatment of tumors. The review also summarizes the limiting factors that affect the development of CDs and possible new advances.
- Carbon dots /
- Synthesis /
- Red emission /
- Diagnosis and therapy

HTML全文

下载: 全尺寸图片幻灯片

参考文献(51)

Xu X, Ray R, Gu Y, et al. Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments[J]. J Am Chem Soc, 2004, 126(40):12736-12737.

Sun Y P, Zhou B, Lin Y, et al. Quantum-sized carbon dots for bright and colorful photoluminescence[J]. J Am Chem Soc, 2006, 128(24):7756-7757.

Wu X, Liu H, Liu J, et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots[J]. Nat Biotechnol, 2003, 21(1):41-46.

Zhu S, Wang L, Zhou N, et al. The crosslink enhanced emission (CEE) in non-conjugated polymer dots:From the photoluminescence mechanism to the cellular uptake mechanism and internalization[J]. Chem Commun, 2014, 50(89):13845-13848.

Dong Y, Pang H, Yang H B, et al. Carbon-based dots co-doped with nitrogen and sulfur for high quantum yield and excitation-independent emission[J]. Angew Chem Int Edit, 2013, 52(30):7800-7804.

Yuan Y H, Liu Z X, Li R S, et al. Synthesis of nitrogen-doping carbon dots with different photoluminescence properties by controlling the surface states[J]. Nanoscale, 2016, 8(1):294-297.

Xiaoyou X, Robert R, Yunlong G, et al. Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments[J]. J Am Chem Soc, 2004, 126(40):12736-12737.

Cao L, Wang X, Meziani M J, et al. Carbon dots for multiphoton bioimaging[J]. J Am Chem Soc, 2007, 129(37):11318-11319.

Lu J, Yang J X, Wang J, et al. One-pot synthesis of fluorescent carbon nanoribbons, nanoparticles, and graphene by the exfoliation of graphite in ionic liquids[J]. ACS Nano, 2009, 3(8):2367-2375.

Bourlinos A B, Stassinopoulos A, Anglos D, et al. Photoluminescent carbogenic dots[J]. Chem Mater, 2008, 20(14):4539-4541.

Zhu H, Wang X, Li Y, et al. Microwave synthesis of fluorescent carbon nanoparticles with electrochemiluminescence properties[J]. Chem Commun, 2009, (34):5118-5120.

Wu Z L, Zhang P, Gao M X, et al. One-pot hydrothermal synthesis of highly luminescent nitrogen-doped amphoteric carbon dots for bioimaging from Bombyx mori silk-natural proteins[J]. J Mater Chem B, 2013, 1(22):2868-2873.

Wang X, Cao L, Yang S T, et al. Bandgap-like strong fluorescence in functionalized carbon nanoparticles[J]. Angew Chem Int Edit, 2010, 122(31):5438-5442.

Anilkumar P, Wang X, Cao L, et al. Toward quantitatively fluorescent carbon-based "quantum" dots[J]. Nanoscale, 2011, 3(5):2023-2027.

Yang S T, Wang X, Wang H, et al. Carbon dots as nontoxic and high-performance fluorescence imaging agents[J]. J Phys Chem C, 2009, 113(42):18110-18114.

Zheng X T, Ananthanarayanan A, Luo K Q, et al. Glowing graphene quantum dots and carbon dots:properties, syntheses, and biological applications[J]. Small, 2015, 11(14):1620-1636.

Miao P, Han K, Tang Y, et al. Recent advances in carbon nanodots:synthesis, properties and biomedical applications[J]. Nanoscale, 2015, 7(5):1586-1595.

Zhao A, Chen Z, Zhao C, et al. Recent advances in bioapplications of C-dots[J]. Carbon, 2015, 85:309-327.

Bhunia S K, Saha A, Maity A R, et al. Carbon nanoparticle-based fluorescent bioimaging probes[J]. Sci Rep, 2013, 3(3):1473.

Dong Y, Wang R, Li H, et al. Polyamine-functionalized carbon quantum dots for chemical sensing[J]. Carbon, 2012, 50(8):2810-2815.

Lei Y, Weihua J, Lipeng Q, et al. One pot synthesis of highly luminescent polyethylene glycol anchored carbon dots functionalized with a nuclear localization signal peptide for cell nucleus imaging[J]. Nanoscale, 2015, 7(14):6104-6113.

Sun X, Brückner C, Lei Y. One-pot and ultrafast synthesis of nitrogen and phosphorus co-doped carbon dots possessing bright dual wavelength fluorescence emission[J]. Nanoscale, 2015, 7(41):17278-17282.

Lihong S, Yanyan L, Xiaofeng L, et al. Facile and eco-friendly synthesis of green fluorescent carbon nanodots for applications in bioimaging, patterning and staining[J]. Nanoscale, 2015, 7(16):7394-7401.

Zhu C, Zhai J, Dong S. Bifunctional fluorescent carbon nanodots:green synthesis via soy milk and application as metal-free electrocatalysts for oxygen reduction[J]. Chem Commun, 2012, 48(75):9367-9369.

Sahu S, Behera B, Maiti T K, et al. Simple one-step synthesis of highly luminescent carbon dots from orange juice:application as excellent bio-imaging agents[J]. Chem Commun, 2012, 48(70):8835-8837.

Wang J, Wang C F, Chen S. Amphiphilic egg-derived carbon dots:rapid plasma fabrication, pyrolysis process, and multicolor printing patterns[J]. Angew Chem Int Edit, 2012, 51(37):9297-9301.

Zhang Z, Sun W, Wu P. Highly photoluminescent carbon dots derived from egg white:facile and green synthesis, photoluminescence properties, and multiple applications[J]. ACS Sustain Chem Eng, 2015, 3(7):1412-1418.

Sun Y P, Wang P, Lu Z, et al. Host-guest carbon dots for enhanced optical properties and beyond[J]. Sci Rep, 2015, 5:12354.

Stan C, Albu C, Coroaba A, et al. One step synthesis of fluorescent carbon dots through pyrolysis of N-hydroxysuccinimide[J]. J Mater Chem C, 2015, 3(4):789-795.

Wang C, Xu Z, Cheng H, et al. A hydrothermal route to water-stable luminescent carbon dots as nanosensors for pH and temperature[J]. Carbon, 2015, 82:87-95.

Xu Y, Jia X-H, Yin X-B, et al. Carbon quantum dot stabilized gadolinium nanoprobe prepared via a one-pot hydrothermal approach for magnetic resonance and fluorescence dual-modality bioimaging[J]. Anal Chem, 2014, 86(24):12122-12129.

Yang Y, Cui J, Zheng M, et al. One-step synthesis of amino-functionalized fluorescent carbon nanoparticles by hydrothermal carbonization of chitosan[J]. Chem Commun, 2012, 48(3):380-382.

Yang Z-C, Wang M, Yong A M, et al. Intrinsically fluorescent carbon dots with tunable emission derived from hydrothermal treatment of glucose in the presence of monopotassium phosphate[J]. Chem Commun, 2011, 47(42):11615-11617.

Hsu P-C, Shih Z-Y, Lee C-H, et al. Synthesis and analytical applications of photoluminescent carbon nanodots[J]. Green Chem, 2012, 14(4):917-920.

Chen B, Li F, Li S, et al. Large scale synthesis of photoluminescent carbon nanodots and their application for bioimaging[J]. Nanoscale, 2013, 5(5):1967-1971.

Yang S, Sun J, Li X, et al. Large-scale fabrication of heavy doped carbon quantum dots with tunable-photoluminescence and sensitive fluorescence detection[J]. J Mater Chem A, 2014, 2(23):8660-8667.

Zhang J, Yuan Y, Liang G, et al. Scale-up synthesis of fragrant nitrogen-doped carbon dots from bee pollens for bioimaging and catalysis[J]. Adv Sci, 2015, 2(4):1-6.

Li L, Lu C, Li S, et al. A high-yield and versatile method for the synthesis of carbon dots for bioimaging applications[J]. J Mater Chem B, 2017, 5(10):1935-1942.

Jiang W, Singhal A, Kim B Y S, et al. Assessing near-infrared quantum dots for deep tissue, organ, and animal imaging applications[J]. Jala-J Lab Autom, 2008, 13(3):6-12.

Agostinis P, Berg K, Cengel K A, et al. Photodynamic therapy of cancer:an update[J]. CA-CANCER J CLIN, 2011, 61(4):250-281.

Pan L, Sun S, Zhang A, et al. Truly fluorescent excitation-dependent carbon dots and their applications in multicolor cellular imaging and multidimensional sensing[J]. Adv Mater, 2015, 27(47):7782-7787.

Ding H, Yu S-B, Wei J-S, et al. Full-color light-emitting carbon dots with a surface-state-controlled luminescence mechanism[J]. ACS Nano, 2015, 10(1):484-491.

Jiang K, Sun S, Zhang L, et al. Red, green, and blue luminescence by carbon dots:Full-color emission tuning and multicolor cellular imaging[J]. Angew Chem Int Edit, 2015, 54(18):5360-5363.

Xiaoyun T, Yunchao L, Xiaohong L, et al. Electrochemical synthesis of small-sized red fluorescent graphene quantum dots as a bioimaging platform[J]. Chem Commun, 2015, 51(13):2544-2546.

Li L, Zhang R, Lu C, et al. In situ synthesis of NIR-Light emission carbon dots derived from spinach for bio-imaging application[J]. J Mater Chem B, 2017, 5(35):7328-7334.

Tao H, Yang K, Ma Z, et al. In vivo NIR fluorescence imaging, biodistribution, and toxicology of photoluminescent carbon dots produced from carbon nanotubes and graphite[J]. Small, 2012, 8(2):281-290.

Hannah A, Luke G, Wilson K, et al. Indocyanine green-loaded photoacoustic nanodroplets:dual contrast nanoconstructs for enhanced photoacoustic and ultrasound imaging[J]. Acs Nano, 2014, 8(1):250-259.

Barreto J A, O'malley W, Kubeil M, et al. Nanomaterials:applications in cancer imaging and therapy[J]. Adv Mater, 2011, 23(12):18-40.

Ge J, Jia Q, Liu W, et al. Red-emissive carbon dots for fluorescent, photoacoustic, and thermal theranostics in living mice[J]. Adv Mater, 2015, 27(28):4169-4177.

Liu Y, Ai K, Liu J, et al. Dopamine-melanin colloidal nanospheres:an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy[J]. Adv Mater, 2013, 25(9):1353-1359.

Ge J, Jia Q, Liu W, et al. Carbon dots with intrinsic theranostic properties for bioimaging, red-light-triggered photodynamic/photothermal simultaneous therapy in vitro and in vivo[J]. Adv Healthc Mater, 2016, 5(6):665-675.

施引文献

资源附件(0)

访问统计