Abstract: In order to increase the adsorption capacity and improve the solid-liquid separation in the post-treatment processes a hybrid graphene oxide-manganese oxide (GOMO) material was fabricated under ultrasonic radiation. The structures and micro-morphology of as-prepared adsorbents were characterized by FT-IR, Raman spectroscopy, SEM and XPS. The effect of solution pH, ionic strength, contact time and initial uranium concentration on uranium removal efficiency was investigated. The adsorption mechanism was investigated by adsorption isotherms, FT-IR and XPS. The solution pH had a significant influence on the removal of uranium. Results showed that GOMO had a favorable adsorption performance. For a uranium solution with an initial concentration of 10 mg/L, the removal rate rapidly reached nearly 100%. The maximum adsorption capacities of GO and GOMO were 75.46 mg/g and 143.34 mg/g, respectively. The adsorption progress of GOMO fitted the Langmuir isotherm model and the pseudo-second-order model well. In the practical applications, the removal efficiency of GOMO for uranium from nuclear industry waste liquid is significantly higher than that of GO.