软木塞基碳量子点的水热合成及其生物相容荧光成像应用

Hydrothermal synthesis of carbon nanodots from waste wine cork and their use in biocompatible fluorescence imaging

    摘要
  • 摘要: 以废弃酒瓶软木塞为原料，采用低成本、简单的水热方法合成碳量子点。通过TEM、FTIR、Raman、UV-Vis、PL光谱对碳量子点的结构和光学性能进行分析表征。结果表明，碳量子点的平均直径为6.2±2.7 nm，PL激发谱和碳量子点表面的官能团有关。用硫酸奎宁作为参考，碳量子点的量子效率为1.54%。将获得的碳量子点应用在骨髓间充质干细胞的细胞生物成像上，发现用碳量子点处理后，骨髓间充质干细胞分别在320~380 nm、450~490 nm和450~490 nm范围显示绿色、黄色和红色荧光，表明了碳量子点在荧光成像领域具有潜在的应用价值。

     

    Abstract: A low-cost and simple method is reported for the synthesis of carbon nanodots (CDs) from waste wine cork using hydrothermal treatment. The structural and optical properties of the CDs were characterized by TEM, FTIR, Raman, UV-Vis absorption, and photoluminescence (PL) spectroscopy. Results indicate that the CDs have an average diameter of ~ 6.2 ± 2.7 nm and their excitation-dependent PL is related to the functional groups on their surface. The CDs have a quantum yield of 1.54%, estimated using quinine sulfate as a reference. They have been successfully applied in the bioimaging of mesenchymal stem cells (MSCs). After treatment with the CDs, the MSCs fluoresce green, yellow and red colors under the excitation wavelengths in the ranges 320-380 nm, 450-490 nm, and 515-560 nm, respectively, demonstrating their potential use in the field of fluorescence imaging.

     

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