Abstract: The rapid development of flexible electronics has made it possible to realize flexible sensors with high sensitivity and a wide detection range. In recent years, the two-dimensional MXene layer materials composed of transition metals, carbon and/or nitrogen have attracted the attention of many researchers in the field of flexible sensors, because of their high conductivity, high specific surface area, outstanding hydrophilicity, excellent mechanical properties and other characteristics. They can be composited with other materials, such as carbon nanotubes, carbon fibers and graphene, to form a variety of materials. Here, the structure and synthesis of MXene materials are introduced, followed by a summary of their preparation methods, structures, performance and sensing mechanisms as flexible sensors. Finally, research trends for flexible sensors using MXene materials are discussed.