Abstract: Adsorption of nifedipine by spherical activated carbons (SACs) and their invitro release behavior were investigated. The pore structure, specific surface area and surface morphologies of the SACs were tested by N2 adsorption and SEM. The relationship between pore structure, specific surface area and adsorption/in-vitro release behavior was discussed. Results indicated that SACs with a high specific surface area and abundant mesopores ranging between 2nm and 5nm exhibited excellent adsorption and in-vitro release of nifedipine. The maximum adsorption capacity was 19.5mg/g, and the total release rate can reach 19.20%. The release dynamics of SACs containing nifedipine are in accordance with the Higuchi model, which shows that the release speed is a constant.