具有优异淋巴示踪特性的纳米炭混悬液的制备

Carbon black (CB) was oxidized by concentrated nitric acid at 100℃ for 100h to obtain a CB with excellent lymphatic tracing properties, which were characterized by XPS, alkalimetric titration and a staining test. It is found that nitric acid treatment obviously increases oxygencontaining functional groups on CB surface. The average diameter of the oxidized CB in suspension is 72nm with no agglomeration found after storage at room temperature for 180days. The suspension prepared with the oxidized CB can effectively color the injecting region of lymph nodes in 5min. The staining effect is superior to a commercial available lymphatic tracer named Carbon Nanoparticle Suspension Injection.